Inline purification in continuous flow synthesis – opportunities and challenges

• Jorge García-Lacuna and
• Marcus Baumann

Beilstein J. Org. Chem. 2022, 18, 1720–1740, doi:10.3762/bjoc.18.182

• reservoirs where each phase enters from the opposite side in relation to density [67]. A somewhat different approach for phase separation has been presented in several studies by Ley and co-workers [68][69][70][71]. The authors developed a ‘computer-vision’ approach, where a computer program monitors the

• separation using a computer-vision approach. Redrawn from [68]. Example of an inline purification using heterogeneous scavenging. Redrawn from [76]. General scheme of a telescoped process using heterogenous cartridges. Comparison of two strategies for flow-based imatinib syntheses. Redrawn from [91] and [92

Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

• Richard J. Ingham,
• Claudio Battilocchio,
• Joel M. Hawkins and
• Steven V. Ley

Beilstein J. Org. Chem. 2014, 10, 641–652, doi:10.3762/bjoc.10.56

• commercial control packages. Established technologies such as chemical intelligence [8], statistical analysis [9] and computer vision [10][11] are available as third-party libraries for easy integration. The simple text-based control scripts can be copied and pasted for simple re-use, and are compatible with

• cameras and computer vision to synthesis procedures. Building on work in which a camera and a float were employed to measure the position of a biphasic (aqueous/organic) mixture within a settling column [5], we manufactured a float containing an air bubble [39] which would float on less dense solvents

• camera was positioned so that it was observing the collection vessel. Regular snapshots were taken and analysed using computer vision software to locate the green float within the image. This information was used to estimate the height of the float in the reservoir, which enabled the control protocol to

Camera-enabled techniques for organic synthesis

• Steven V. Ley,
• Richard J. Ingham,
• Matthew O’Brien and
• Duncan L. Browne

Beilstein J. Org. Chem. 2013, 9, 1051–1072, doi:10.3762/bjoc.9.118

• Abstract A great deal of time is spent within synthetic chemistry laboratories on non-value-adding activities such as sample preparation and work-up operations, and labour intensive activities such as extended periods of continued data collection. Using digital cameras connected to computer vision

• of the future. Keywords: automation; computer vision; digital camera; flow chemistry; machine-assisted synthesis; Introduction The increasing prevalence of digital camera technology for capturing images, videos and visible information is having a profound impact on many aspects of our modern

• other enabling technologies [16][33][34][35] are receiving increased attention. With the continuing development of digital imaging technology, computer vision techniques and laboratory automation, some of these routine tasks may be delegated to a computer. Not only will this allow skilled researchers to